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Dunkle Research Group
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Principal Investigator - Jack A. Dunkle, Ph.D.

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Jack received a B.S. in Chemistry from the University of Alabama at Birmingham in 2005 where he performed undergraduate research in the Department of Microbiology and Immunology with Dr. Charles L. Turnbough. Jack then performed graduate research with Dr. Jamie H. D. Cate at UC-Berkeley solving x-ray crystal structures of the E. coli ribosome to determine the structural mechanisms controlling mRNA and tRNA translocation during protein synthesis. Jack also elucidated the binding sites of several clinically important antibiotics on the E. coli ribosome and was awarded a Ph.D. in Molecular and Cell Biology in 2010.

Jack received postdoctoral training from Drs. Christine M. Dunham and Graeme L. Conn in the Department of Biochemistry at Emory University. At Emory, Jack studied how the ribosome avoids frameshift errors while reading the genetic code and also determined how a class of RNA methyltransferases recognize and methylate rRNA to confer resistance to aminoglycoside antibiotics.

In 2015, Jack became an Assistant Professor of Chemistry and Biochemistry at the University of Alabama and in 2021 was promoted to Associate Professor. At UA, the Dunkle Research Group is studying the specificity mechanisms of erythromycin resistance rRNA methyltransferases a clinically important antibiotic resistance determinant, the structure and function of proteins in the Suf Fe-S biosynthesis pathway and the specificity and interference mechanisms of CRISPR-Cas10. The Dunkle Group has been funded by the National Institutes of Health and the National Science Foundation.

Current Group Members

Sarah Khweis - Graduate student
Johnny Herbert - Graduate student
Danielle McGaha - Graduate student
Luqman Ajisafe - Graduate student
Luke Mondia - Undergraduate student
Karen Fetsch - Undergraduate student
Colby Lewis - Undergraduate student
Mason Blackburn - Undergraduate student

Alumni

Malcolm Luttrull - Current: Chemical industry scientist
Andrew Beckman - Current: High school science teacher
Mary Muffly - Current: University of Miami Medical School
Joshua Halliday - Current: Biotechnology scientist
Christina Schoose - Current: University of Phoenix Master's Program in Public Health
Rachel Talton - Current: University of Mississippi Medical School
Sebastian Rowe - Current: Harvard University Ph.D. Program in Chemical Biology
Zoe Guckien - Current: Indiana University Medical School
Georgette Munezero - Current: Master's Program in Global Health
Hannah Wineinger - Current: PhD student at Florida State University
Michael Bruno - Current: Medical College of Georgia
Alexandra Yungblut - MD/PhD student at the University of Toledo
Ryan Mecaskey - Current: Virginia Commonwealth University School of Medicine
Rory Sharkey - Current: PhD student Rice University
Caroline Yuk - Current: Marshall Scholar at Oxford University
Taylor Culpepper - Current: Graduate student at Vanderbilt University
Mohamed Nasef - Current: Postdoctoral fellow at the University of Alabama at Birmingham
Dalton Morris
Reid Petersen - Current: University of Tennessee College of Medicine
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