Publications
2020
Rowe, S. J., Mecaskey, R.J., Nasef, M., Talton, R.C., Sharkey, R.E., Halliday, J.C. and Dunkle, J.A. (2020). Shared requirements for key residues in the antibiotic resistance enzymes ErmC and ErmE suggest a common mode of RNA recognition. J Biol Chem 295(51) 17476-17485. doi.org/10.1074/jbc.RA120.014280
Dunkle, J.A., Bruno, M.R. and Frantom, P.A. (2020) Structural evidence for a latch mechanism regulating access to the active site of SufS-family cysteine desulfurases. Acta Cryst. D 76, 291-301. https://doi.org/10.1107/S2059798320000790.
Dunkle, J.A., Bruno, M.R. and Frantom, P.A. (2020) Structural evidence for a latch mechanism regulating access to the active site of SufS-family cysteine desulfurases. Acta Cryst. D 76, 291-301. https://doi.org/10.1107/S2059798320000790.
2019
Blahut, M., Wise, C. E., Bruno, M. R., Dong, G., Makris, T. M., Frantom, P. A., Dunkle, J. A., and Outten, F. W. (2019) Direct observation of intermediates in the SufS cysteine desulfurase reaction reveals functional roles of conserved active-site residues. J Biol Chem ePub:2019/06/30 DOI:10.1074/jbc.RA119.009471.
Nasef, M., Muffly, M. C., Beckman, A. B., Rowe, S. J., Walker, F. C., Hatoum-Aslan, A., and Dunkle, J. A. (2019) Regulation of cyclic oligoadenylate synthesis by the Staphylococcus epidermidis Cas10-Csm complex. RNA 25, 948-962.
Dunkle, J.A., Bruno, M.R., Outten, F.W., and Frantom, P.A. (2019). Structural Evidence for Dimer-Interface-Driven Regulation of the Type II Cysteine Desulfurase, SufS. Biochemistry 58, 687-696.
Nasef, M., Muffly, M. C., Beckman, A. B., Rowe, S. J., Walker, F. C., Hatoum-Aslan, A., and Dunkle, J. A. (2019) Regulation of cyclic oligoadenylate synthesis by the Staphylococcus epidermidis Cas10-Csm complex. RNA 25, 948-962.
Dunkle, J.A., Bruno, M.R., Outten, F.W., and Frantom, P.A. (2019). Structural Evidence for Dimer-Interface-Driven Regulation of the Type II Cysteine Desulfurase, SufS. Biochemistry 58, 687-696.
2018
Hong, S., Sunita, S., Maehigashi, T., Hoffer, E.D., Dunkle, J.A. and Dunham, C.M. (2018) Mechanism of tRNA-mediated +1 ribosomal frameshifting. Proc Natl Acad Sci U S A.
2017
Walker, F.C., Chou-Zheng, L., Dunkle, J.A., and Hatoum-Aslan, A. (2017). Molecular determinants for CRISPR RNA maturation in the Cas10-Csm complex and roles for non-Cas nucleases. Nucleic Acids Res 45(4), 2112-2123.
2015
Schureck, M.A., Dunkle, J.A., Maehigashi, T., Miles, S.J., and Dunham, C.M. (2015). Defining the mRNA recognition signature of a bacterial toxin protein. Proc Natl Acad Sci U S A 112, 13862-13867.
Dunkle, J.A., and Dunham, C.M. (2015). Mechanisms of mRNA frame maintenance and its subversion during translation of the genetic code. Biochimie 114, 90-96.
Dunkle, J.A., and Dunham, C.M. (2015). Mechanisms of mRNA frame maintenance and its subversion during translation of the genetic code. Biochimie 114, 90-96.
2014
Maehigashi, T., Dunkle, J.A., Miles, S.J., and Dunham, C.M. (2014). Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops. Proc Natl Acad Sci U S A 111, 12740-12745. Pubmed link
Fagan, C.E., Maehigashi, T., Dunkle, J.A., Miles, S.J., and Dunham, C.M. (2014). Structural insights into translational recoding by frameshift suppressor tRNASufJ. RNA 20, 1944-1954.
Dunkle, J.A., Vinal, K., Desai, P.M., Zelinskaya, N., Savic, M., West, D.M., Conn, G.L., and Dunham, C.M. (2014). Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. Proc Natl Acad Sci U S A 111, 6275-6280.
Fagan, C.E., Maehigashi, T., Dunkle, J.A., Miles, S.J., and Dunham, C.M. (2014). Structural insights into translational recoding by frameshift suppressor tRNASufJ. RNA 20, 1944-1954.
Dunkle, J.A., Vinal, K., Desai, P.M., Zelinskaya, N., Savic, M., West, D.M., Conn, G.L., and Dunham, C.M. (2014). Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. Proc Natl Acad Sci U S A 111, 6275-6280.
2013
Fagan, C.E., Dunkle, J.A., Maehigashi, T., Dang, M.N., Devaraj, A., Miles, S.J., Qin, D., Fredrick, K., and Dunham, C.M. (2013). Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state. Proc Natl Acad Sci U S A 110, 9716-9721.
Dunkle, J.A., and Cate, J.H. (2013). An Introduction to the Structure and Function of the Ribosome. EcoSal Plus 5.
Dunkle, J.A., and Cate, J.H. (2013). An Introduction to the Structure and Function of the Ribosome. EcoSal Plus 5.
2012
McGinnis, J.L., Dunkle, J.A., Cate, J.H., and Weeks, K.M. (2012). The mechanisms of RNA SHAPE chemistry. J Am Chem Soc 134, 6617-6624.
2011
Dunkle, J.A., Wang, L., Feldman, M.B., Pulk, A., Chen, V.B., Kapral, G.J., Noeske, J., Richardson, J.S., Blanchard, S.C., and Cate, J.H. (2011). Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. Science 332, 981-984.
2010
Llano-Sotelo, B., Dunkle, J., Klepacki, D., Zhang, W., Fernandes, P., Cate, J.H., and Mankin, A.S. (2010). Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis. Antimicrob Agents Chemother 54, 4961-4970.
Dunkle, J.A., Xiong, L., Mankin, A.S., and Cate, J.H. (2010). Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc Natl Acad Sci U S A 107, 17152-17157.
Dunkle, J.A., and Cate, J.H. (2010). Ribosome structure and dynamics during translocation and termination. Annu Rev Biophys 39, 227-244.
Dunkle, J.A., Xiong, L., Mankin, A.S., and Cate, J.H. (2010). Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc Natl Acad Sci U S A 107, 17152-17157.
Dunkle, J.A., and Cate, J.H. (2010). Ribosome structure and dynamics during translocation and termination. Annu Rev Biophys 39, 227-244.
2009
Zhang, W., Dunkle, J.A., and Cate, J.H. (2009). Structures of the ribosome in intermediate states of ratcheting. Science 325, 1014-1017.
